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Ensuring American Pharmaceutical Supply Chain Resilience by Filling the Strategic Active Pharmaceutical Ingredients Reserve

President Donald Trump issued Executive Order 14336 to enhance the resilience of the American pharmaceutical supply chain by filling the Strategic Active Pharmaceutical Ingredients Reserve (SAPIR). The order directs the Office of the Assistant Secretary for Preparedness and Response (ASPR) to develop a list of approximately 26 critical drugs and to secure a 6-month supply of active pharmaceutical ingredients (APIs) for these drugs, prioritizing domestic production when possible. The ASPR is tasked with preparing the SAPIR repository to receive and maintain these APIs within specified timelines. The order aims to reduce reliance on foreign sources for APIs and bolster national health and security interests.